BDBComp
Parceria:
SBC
Large scale protein function prediction tools

Raquel C. de Melo MinardiFrançois ArtiguenaveGoran Neshich

In this project we intend to reinforce a recent collaboration established between two French and Brazilian bioinformatics laboratories for the development of a structural genomics approach to functional annotation of proteins. From initial works, we explored a new methodology for protein annotation based on modeled structural data. During this work, we identified that new tools will have to be designed for large scale protein function prediction. In this proposal, we would like to analyze the results of the proposed methodology with proteins of known function as well as analyze the impact of the use of different known techniques for each of its steps (homology modeling, cavity detection, binding / active site prediction and clustering according to subfamily specificity). We will possibly develop new algorithms in order to gain quality in prediction.

http://www.lbd.dcc.ufmg.br/colecoes/colibri/2009/011.pdf

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Biblioteca Digital Brasileira de Computação - Contato: bdbcomp@lbd.dcc.ufmg.br
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LBD