A. C. Q. Simões,  A. M. da Silva,  E. M. Reis,  S. Verjovski-Almeida. 

In order to select gene markers among differentially expressed transcripts identified from tumoral prostate, we have applied a filter and Significance Analysis of Microarrays (SAM) as the feature selection method on a previously normalized dataset of DNA microarray experiments reported by Reis et al., 2004 (Oncogene 23:6684-6692). Twenty seven samples with different degrees of tumor differentiation (Gleason scores) were analyzed. SAM was run using either two-class, unpaired data analysis with Gleason 5-6 and Gleason 9-10 samples, or multiclass response analysis with an additional category of Gleason 7-8. Both strategies revealed a promising set of transcripts associated with the degree of differentiation of prostate tumors.

http://www.lbd.dcc.ufmg.br/colecoes/bsb/2005/034.pdf

Processando consulta.