Fernando Luis de Almeida, Marcelo Bariatto Andrade Fontes.
The development of a catheter based biosensor forreal time and in situ monitoring of biological signals isdescribed. Our main application is the detection ofparacetamol, a well-known chemical for pain and feverrelieve. The biosensor is based on the electrochemicalreaction of this radical at the surface of the detectionelectrode made of gold, using silver chlorine (Ag/AgCl)as reference electrode and a platinum auxiliary electrode.All electrodes were made by wires (?=200 ?m) andassembled on to catheter (?e= 1.34 mm). Amperometrictechnique was used for paracetamol detection and cyclicvoltammetry for gold electrode characterization, mainlyits area, which is important to determine the sensibilityand to assert the reproducibility of the sensor. Bothtechniques were performed by using a CV-50WBionalytical System (BAS) electrochemical workstation.The sensor was able to detect concentration as low as0.17 mmol.L-1 of paracetamol which is the usual valuefound in the blood. We applied this sensor to obtain theamount of active principle in tablets of Tylenol®.
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