Mining Structural Signatures of Proteins

Raquel C. MeloJanaina S. GomidePhillippe S. L. DiasWagner Meira Jr.Marcelo M. Santoro

Proteins are the most important macromolecules in living systems. It is well known that their function is totally dependent on their structure. How- ever, identical structures can be formed by very dissimilar amino acid sequences and little is known about how so different sequences fold into identical struc- tures and functions. In this work, we propose a clustering approach to obtain patterns of amino acid chemical interactions in protein families that compose a structural signature for each family.

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